A Window of Opportunity: Targeting Cancer Endothelium to Enhance Immunotherapy
Vascular abnormalities in tumors have a major impact on the immune microenvironment in tumors.The consequences of abnormal vasculature include increased hypoxia, acidosis, high intra-tumoral fluid pressure, and angiogenesis.This introduces an immunosuppressive microenvironment that alters immune cell maturation, activation, and trafficking, which s